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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: Pseudo Biologist who wrote (2800)11/15/1997 1:06:00 AM
From: JOHN W.  Read Replies (1) of 6136
 
Subject: integrases
Date: Fri, Nov 14, 1997 18:34 EST
From: Taurus8266
Message-id: <19971114233401.SAA02437@ladder01.news.aol.com>

Researchers are far from sure how long infected memory T cells will live before finally dying out, perhaps taking the virus into oblivion with them. Several years ago, immunologists Angela McLean of Oxford University and Colin Michie at London's Ealing Hospital showed that while the average memory T cell lives for about 200 days, some individual cells could survive for many years....But leaving these cells on their own is the last thing
AIDS researchers intend to do. "We must hasten the demise of these cells," says Coffin...Another approach, Fauci says, would be to develop new drugs against HIV enzymes called integrases--which allow the virus to take over the genetic machinery of its target cells--hence stopping the formation of hidden HIV reservoirs. Says Ho: "These new results tell us what we must do in the upcoming year. They shed light on the path to eliminating the
virus from an infected person, the ultimate goal for those of us working on HIV therapeutics."

Volume 278, Number 5341 Issue of 14 November 1997, p 1227
c1997 by The American Association for the Advancement of Science. 1.6

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