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Biotech / Medical : Agouron Pharmaceuticals (AGPH)
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To: Oliver & Co who wrote (2819)11/16/1997 12:01:00 PM
From: Andreas Helke  Read Replies (1) of 6136
 
In the PNAS study of Chun et. al. the test used had a detection limit of 500/ml but they found hints of virus replication in all 18 patients. I would assume that at least some of them would have below 20 copies /ml if a more sensitive test would have been used.


Chun T-W, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA 1997;94:13193-7.

"In addition to integrated HIV DNA, the investigators found unintegrated DNA in cells from all patients."
"The presence of unintegrated HIV DNA suggests that a low level of viral replication may continue even in the setting of HAART," notes Dr. Fauci. "In HAART-treated patients, we found that levels of unintegrated HIV DNA were 28 times higher than integrated HIV DNA levels. This suggests that even when HIV is undetectable in the plasma, a low degree of viral replication contributes to the maintenance of a reservoir of HIV-infected CD4+ T cells."
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