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Biotech / Medical : Ligand (LGND) Breakout!
LGND 203.41-1.4%12:59 PM EST
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To: squetch who wrote (11644)11/24/1997 7:27:00 PM
From: Abuckatatime  Read Replies (1) of 32384
 
squetch,>>I thought there was an increased risk.<< You are right, there is. A recent Lancet article (vol.350:Oct11,1997)describes the results of a large meta-analysis in which investigators reanalyzed data from over 50 epidemiological studies conducted over the last 25 years. They found an increased risk of breast cancer in current or recent users of HRT for more than five years and the risk was related to duration of use, increasing by a factor of 1.023 for each year of use. This translates to 12 extra cases of breast cancer by age 70 for every 1000 women who start taking HRT at age 50 and continue it for 20 years. Results of randomized prospective controlled trials won't be available to answer some of the questions regarding the epidemiological findings for a few more years. In the US a large trial involving 275,000 women taking HRT is ongoing and should be concluded by 2007. The epidemiological data will have to do for a while, and they point to an increased risk with HRT. There are clear benefits to HRT, ie reduction in overall and cardiovascular mortality, fewer fractures, less colon cancer, and perhaps protection against neurlogic decline. These have to be weighed by patient and clinician against the risks, on a case by case basis.
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