JAMA 11/17/97
Found this in the Journal of the American Medical Association
JAMA - Women's Health
Dated: 11/17/97
ama-assn.org
Increased Sensitivity to HIV-1 Antibody Detection
Nature Medicine (11/97) Vol. 3, No. 11, P. 1258; Urnovitz, Howard B.; Sturge,
Jerrilyn C.; Gottfried, Toby D.
Researchers from Calypte Biomedical in California report that accurate diagnosis of HIV-1 infection improves when tests of both blood products and urine are made.
A recent study, conducted in support of U.S. licensure of the Calypte HIV-1 urine enzyme immunassay (EIA), analyzed 11,344 paired urine and serum samples. Of the total, 10,163 had urine and serum either EIA non-reactive or western blot (WB) negative or indeterminate for HIV-1 antibodies, while 1,156 had serum and urine that was WB-positive.
The remaining 25 individuals were WB-positive in one but not the other. Of those, 10 had urine that was WB-confirmed positive and serum that was EIA non-reactive and WB negative or indeterminate; while 15 had serum that was WB-confirmed positive and urine that was EIA non-reactive or WB negative or indeterminate.
By pairing samples, diagnosis of HIV-1 infection increases in accuracy, the researchers said. |
