Indications -- Cancer Message Board

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Biotech / Medical : Indications -- Cancer

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To: idos who wrote (1706)	11/18/2012 1:52:32 PM
From: idos	of 1840

Preclinical basic research Dedifferentiation of Neurons and Astrocytes by Oncogenes Can InduceGliomas in Mice http://www.sciencemag.org/content/early/2012/10/18/science.1226929.abstract?sid=05b326b4-edb6-4266-85fd-860dfbcb9191 ABSTRACT Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor inhumans. Here, we show that gliomas can originate from differentiated cells in the central nervous system (CNS), including cortical neurons. Transduction by oncogenic lentiviral vectors of neural stem cells (NSCs), astrocytes, or even mature neurons in the brain of mice can give rise to malignant gliomas. All the tumors, irrespective of the site of injection (initiating population), share common features of high expression of stem or progenitor markers and low expression of differentiation markers. Microarray analysis revealed that tumors of astrocytic and neuronal origin match the mesenchymal GBM subtype. We propose that most differentiated cells in the CNS upon defined genetic alterations undergodedifferentiation to generate a NSC or progenitor state to initiate and maintain the tumor progression, as well as to give rise to the heterogeneous populations observed in malignant gliomas.

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