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Biotech / Medical : Stem Cell Research

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From: nigel bates	1/18/2013 9:09:55 AM
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Reprogramming Adult Schwann Cells to Stem Cell-like Cells by Leprosy Bacilli Promotes Dissemination of Infection cell.com Cell, Volume 152, Issue 1, 51-67, 17 January 2013 Copyright © 2013 Elsevier Inc. All rights reserved. 10.1016/j.cell.2012.12.014 Highlights Leprosy bacteria reprogram adult Schwann cells by altering host-gene expression Bacterially reprogrammed cells resemble progenitor/stem-like cells (pSLC) of mesenchymal trait pSLC promote bacterial spread to mesenchymal tissues by redifferentiation pSLC secrete immune factors, recruit macrophages, transfer bacteria, form granulomas, and disseminate infection

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