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Biotech / Medical : BSD Medical (Long Term Investment Oriented)

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To: fwhco who wrote (102)2/7/2013 12:03:21 PM
From: pleonastic   of 178
 
Thanks, fwco. There are some very interesting comments in that abstract; every statement, in fact. It provides a good venue for reviewing the reasons for the proven successes of hyperthermia (and *microwave* hyperthermia is the BEST – and BSD Medical is the *worldwide leader* in microwave hyperthermia):



“The hallmarks of hyperthermia and its pleotropic effects are in favour of its combined use with chemotherapy.”



A long list of successful trials are provided at BSD Medical.com.



“Thermal enhancement of drug cytotoxicity is accompanied by cellular death and necrosis without increasing its oncogenic potential. “



One reason for this is the strong tendency of heated tumors to be more permeable to whatever drug is involved. Also, the tumor’s defense mechanisms tend to be defeated at the raised temperatures. Also, the body’s defense mechanisms are stimulated (as below). These things should provide much-enhanced drug therapy, and many trials have shown that they do.



“The induction of genetically defined stress responses can deliver danger signals to activate the host’s immune system.”



I’ve seen this claim in at least several places. It seems well established.



“The positive results of randomised trials have definitely established hyperthermia in combination with chemotherapy as a novel clinical modality for the treatment of cancer.”



Again, these results are listed at the BSD Medical website. Seems to me that the success of these trials – with very substantial positive results and little to no negatives (efficacy failures or serious additional side effects) – reasonably assure eventual wide acceptance of hyperthermia (even in the world-lagging U.S.!)



As a side note (drawn mainly from scuttlebutt from long-time investors), initial investigations (decades ago) of hyperthermia were badly flawed and led to mistaken views about the therapy. This has, no doubt, slowed acceptance of the practice. I think these early trials are no longer influential.



“Hyperthermia targets the action of chemotherapy within the heated tumour region without affecting systemic toxicity. In specific clinical settings regional hyperthermia (RHT) or hyperthermic perfusion has proved its value and deserve a greater focus and investigation in other malignancies.”



Well – duh! J



“In Europe, more specialised centres should be created and maintained as network of excellence for hyperthermia in the field of oncology. “



“The European cancer centers have been way ahead of the U.S. in seeing the positive effects of hyperthermia as an adjunct to chemo drugs.”



Indeed! And, the same goes for microwave ablation, as well.
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