MorphoSys Receives First Patent on Novel Antibody Platform Ylanthia in the US
February 08, 2013 / 7:30 am, CET
MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) today announced that the US Patent and Trademark Office (USPTO) has granted the first patent covering the Company's latest antibody platform Ylanthia, which became commercially available for existing and new partners in 2012.
"A growing patent portfolio on our new antibody platform Ylanthia is an important factor for a successful partnering process in our core licensing markets, which we intend to intensify during the course of 2013", commented Dr. Marlies Sproll, Chief Scientific Officer of MorphoSys AG.
The new patent (US 8,367,586) covers the composition of MorphoSys's Ylanthia antibody library. Ylanthia comprises more than 100 billion distinct, fully human antibodies, which makes it the industry's largest known antibody Fab library. It uses 36 fixed, naturally-occurring heavy and light chain framework combinations, which translates into unprecedented structural diversity. The library's diversity is expected to result in antibodies against previously inaccessible target molecules and unique epitope coverage.
Ylanthia's antibody frameworks were pre-selected for expression levels, stability and aggregation behavior. A shift towards higher stability and stress tolerance will increase shelf life and serum stability of resulting antibody products, making them more cost-effective to produce and administer. A higher solubility in turn opens up the path for more convenient ways of administration, to the benefit of patients. When needed, antibodies from the Ylanthia library are optimized using MorphoSys's proprietary Slonomics technology. Slonomics enables optimization of Ylanthia antibodies with unprecedented speed and flexibility.
About MorphoSys:
.....
morphosys.com |
