Provectus Pharmaceuticals Inc. Message Board

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Biotech / Medical : Provectus Pharmaceuticals Inc.

PVCT 0.0700

+0.3%

Nov 21 3:07 PM EST

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To: Mimbari who wrote (11769)	2/17/2013 6:37:57 AM
From: NTTG	1 Recommendation Read Replies (1) of 13111

LOL..OK, no point try to to argue with that logic, but you might want to read through the study design for the Moffitt trial, pay particular attention to the timing of the primary lesion treatment and subsequent initiation of lung mets. Might also want to read the companies position of global broad based vaccine effects, and a bit on basic immunology. The company claim is that you don't have to "try" to treat the bystander, it is the 'immune mediated' bennie that results from PV-10 Tx..they want investors to believe that patients achieve two effects with PV-10; primary Tx and bystander effect. You don't have to jump to any conclusion from the care report other that the obvious..the patient was not protected from subsequent metastatic disease by PV-10, the companies global argument did not stand the test of clinical experience. Would argue the same is true for the PII bystander effect in that there is no control group to compare 'natural disease' to the events that occur in PV-10 treated groups, but I know you have already come to a conclusion on that too. I guess if you wanted to claim a silver lining here you would draw attention to the fact that only 1 of 2 cases developed pulmonary mets; so I guess you would conclude a 50% success rate in CR prevention since the other patient did not develop them...in the time frame reported. That would make this case report more successful that the bystander CR reported for PII, but not quite as good as the 3/5 Moffitt data. Or you could just ignore the obvious fact that patients treated with PV-10 do not generate robust immune responses, which you already saw in the poor bystander response rates in the PII trial BTW, this company has never been timid about sharing what they know, and think they know, with investors. Good luck with your investment...amazing

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