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Biotech / Medical : Biotech News
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To: Biotech Jim who wrote (7036)3/12/2013 5:30:26 PM
From: Biotech Jim   of 7143
 
I have read much of the Nature paper now and the problems in my view are the data underlying fig s4. That is, the proteins that interact with and thus are functionally associated with the specific HDACs and LDACs. Here is a quote from the paper 'that appears to stretch the truth.'

"Page 2 of pdf: 878 genetic interactions of human KDACs were validated from 307 candidates (Supplementary Table 1 and 2)." quote taken from page 2 of the pdf.

Fig s1 is also problematic in my view in terms of replication, that is choose not the most representative data but the 'best' data. Thus, the questionable derived data results in a very beautiful interaction figure in that of fig s5, one that wows the non-expert in terms of the perceived understanding of this set of proteins. Same story for the deduced data in Fig 1 of the primary paper. On the other hand, the direct biochemical evaluations of the specific proteins in the various figures are believable where shown, presuming they would reproduced over multiple experiments.
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