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Biotech / Medical : Incyte (INCY)
INCY 104.09-1.3%Nov 14 9:30 AM EST
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To: tommysdad who wrote (2878)6/29/2013 12:11:31 AM
From: Biomaven   of 3202
 
I do recall the Sepracor antihistamine drug that ultimately got derailed because of a long-lasting minor metabolite. But there I think there was some issue of accumulation in tissue.

And that that is a good thing. Because . . . I lose the thread at that point.
Well they claim it potentially allows QD dosing, which would indeed be a good thing.

I believe there are at least a few dozen approved drugs (not designed as pro-drugs) where the active metabolite turns out to have the dominant activity - e.g., risperidone and tramadol. There are others where the active metabolite contributes to the activity (like Prozac) but isn't dominant.

So this may not be elegant, but not sure how much of a problem it will actually be for them (assuming, as you hypothesize, that the tox species make the same metabolite in similar amounts).

Peter
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