SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Incyte (INCY)
INCY 108.15+2.1%3:59 PM EST
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: scaram(o)uche who wrote (2914)8/24/2013 3:01:52 PM
From: scaram(o)uche   of 3202
 
another fun one, don't know how I missed it.....

ncbi.nlm.nih.gov

In summary, we highlight Treg as critical cells involved in suppressing the anti-glioma immune response. This mechanism involves the co-inhibitory ligand CTLA-4, is therapeutically modulated with Treg-depleting CD25 mAb and Treg function-modulating GITR agonistic mAb. We also highlight the tryptophan catabolizing enzyme, IDO1, as a critical modulator of Treg recruitment and/or expansion to/within the glioma, as well as raise the possibility that enzymes with similar catabolic activity, IDO2 and TDO, may be attractive future targets for immunotherapeutic consideration. With these insights in mind, Treg immunomodulation as a means to increase GBM immunogenicity appears to be a rapidly developing approach.
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News