PTC Therapeutics -- PTCT Message Board

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Biotech / Medical : PTC Therapeutics -- PTCT

PTCT 68.31

+0.3%

Oct 31 9:30 AM EDT

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To: scaram(o)uche who wrote (2)	1/24/2014 1:10:56 PM
From: tuck	Read Replies (2) of 38

Good warning as EMA says no: EMA says no to ataluren Company has said it will appeal in hopes of submitting a confirmatory study based on further enrollment because the walking distance numbers are claimed to be good. Stock is holding up well under the circumstances. I wouldn't expect that they're in any better shape with the FDA. The BMI-1 program you point to is preclinical. You know that, of course, just putting it out there with the thought that it's worth watching, with plenty of time on the clock. Know nothing of competing programs for that target. Their candidate phosphorylates BMI-1, thus deactivating it. Apparently, BMI-1 expresses only on carcinogenic stem cells, so toxicity is expected to be slight. So far, a few xenograft mice have done OK on it, FWIW. pipeline Cheers, Tuck

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