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Biotech / Medical : PTC Therapeutics -- PTCT

PTCT 68.31

+0.3%

Oct 31 9:30 AM EDT

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To: scaram(o)uche who wrote (5)	1/26/2014 11:58:34 AM
From: scaram(o)uche	Read Replies (1) of 38

This brilliant exchange on twitter today re. CD123 (MGNX, XNCR).... Andy Biotech ?@AndyBiotech 18h @DrMiguelPerales Penn CD123 CART showed nice efficacy in mice but also clear BM tox, heard they won't pursue further ash.confex.com … Reply Retweet Favorite More Expand Miguel Perales M.D. ?@DrMiguelPerales 18h @AndyBiotech BM Toxicity of CD123 CART could be built into Allo-HCT conditioning - need to make sure CART are gone when donor graft goes in Reply Retweet Favorite More Expand Andy Biotech ?@AndyBiotech 18h @DrMiguelPerales Thx! Is it better to target CD123 w mAbs, bi-specific CD3xCD123 Abs or ADCs given the safety concerns and narrow Tx window? Reply Retweet Favorite More Expand Miguel Perales M.D. ?@DrMiguelPerales 18h @AndyBiotech Pros & cons to bi-spec Abs vs CART in general. At this stage, we should explore both. For CD123 bi-spec may have better profile Reply Retweet Favorite More Expand Andy Biotech ?@AndyBiotech 18h @DrMiguelPerales Agreed and it's clearly on industry's radar, both $MGNX and $XNCR have CD123 bi-spec in development ash.confex.com … Hide conversation Reply Retweet Favorite More 2Retweets 1Favorite jjz Miguel Perales M.D. 9:43 AM - 26 Jan 2014 · Details

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