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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ)
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To: Zebra 365 who wrote (3543)12/13/1997 4:02:00 PM
From: Bradpalm1  Read Replies (1) of 23519
 
Zebra,

I absolutely agree with you. Mechanistically, Muse and Viagra ARE potentially synergistic products for the treatment of organic ED due to their differing modes of action (alprostadil increases cAMP while sildenafil increases cGMP in the penis). This dual mode may provide those individuals with a less than optimal response to Viagra with the 'diamond cutter' they're looking for (and STILL avoid the needle!). This needs to be kept in mind as we await for the approval of Viagra in Q2 of next year.

However, the more I think about it, I'm not so willing anymore to give Viagra (and Pfizer) a free pass on this 'blue halo' effect noted in some individuals (occurred in 3-4% of those taking Viagra and lasted 10-20 minutes). IF directly related to PDE inhibition in the retina, then there COULD be a problem here as more individuals use this product for longer periods of time. No one here is a bigger fan of Pfizer than me (except BigKNY3, of course), but I still haven't gotten a satisfactory response from my ophthalmological colleagues concerning the benign nature of this effect. Perhaps Cacaito and Tunica were on to something afterall. Dr. Bond also alluded to a 'rumor' about information contained in the submitted Phase III studies for Viagra. It should be very interesting.

Bradpalm1
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