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Biotech / Medical : Ligand (LGND) Breakout!
LGND 186.64-2.0%Feb 9 3:59 PM EST

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From: nigel bates6/25/2014 8:52:41 AM
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Ligand Pharmaceuticals Incorporated (LGND) announces that its partner GlaxoSmithKline (GSK) plc has started a Phase 3 study to evaluate the platelet supportive care effects of eltrombopag (Promacta™/Revolade™) in combination with azacitidine (the current standard of care) versus placebo in combination with azacitidine in intermediate-1, intermediate-2 or high-risk patients with myelodysplastic syndromes (MDS). The global SUPPORT (TRC112121) study will assess the proportion of patients who are platelet transfusion free during the first four cycles of treatment.

MDS is a type of cancer in which the bone marrow does not make enough healthy blood cells and there are abnormal (blast) cells in the blood and/or bone marrow1. The disease usually manifests itself with one or more cytopenias, or reductions in the number of blood cells, and patients typically present with complications related to anemia (fatigue), neutropenia (infections) or thrombocytopenia (bleeding)2. MDS may evolve into acute myeloid leukemia (AML) in up to 45% of patients.3

“With the start of the SUPPORT trial GSK continues to advance eltrombopag in multiple indications to boost platelets to treat thrombocytopenia, including clinical programs and regulatory approvals in oncology and infectious disease indications,” said John Higgins, President and CEO of Ligand Pharmaceuticals. “GSK has maintained a comprehensive global view of brand management and a deep commitment to maximizing the reach of Promacta/Revolade to patients with significant unmet needs. The SUPPORT trial is one of more than 25 active clinical trials underway with eltrombopag.”...
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