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Biotech / Medical : Xencor (XNCR)

XNCR 14.37

+5.0%

Nov 5 3:59 PM EST

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From: scaram(o)uche

8/12/2014 1:35:01 PM

of 136

Handy table from a MGNX patent published today.....

TABLE 1

Receptors for the Fc Regions of Immunoglobulin Isotypes
Receptor	Binding	Cell Type	Effect of Ligation

Fc?RI	IgG1	Macrophages	Uptake
(CD64)	108 M-1	Neutrophils	Stimulation
		Eosinophils	Activation of respiratory burst
		Dendritic cells	Induction of killing
Fc?RII-A	IgG1	Macrophages	Uptake
(CD32)	2 × 106 M-1	Neutrophils	Granule release
		Eosinophils
		Dendritic cells
		Platelets
		Langerhan cells
Fc?RII-B1	IgG1	B cells	No uptake
(CD32)	2 × 106 M-1	Mast cells	Inhibition of Stimulation
Fc?RII-B2	IgG1	Macrophages	Uptake
(CD32)	2 × 106 M-1	Neutrophils	Inhibition of Stimulation
		Eosinophils
Fc?RIII	IgG1	NK cells	Induction of Killing
(CD16)	5 × 105 M-1	Eosinophils
		Macrophages
		Neutrophils
		Mast Cells
FceRI	IgE	Mast cells	Secretion of granules
	1010 M-1	Eosinophil
		Basophils
FcaRI	IgA1, IgA2	Macrophages	Uptake
(CD89)	107 M-1	Neutrophils	Induction of killing
		Eosinophils

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