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OFF TOPIC. Henry, it is my understanding that Kaposi's sarcoma (KS) is caused by human herpesvirus-8 (HHV-8), which is found in 100% of KS tissue. HHV-8 is found in sperm, semen, B lymphocytes, endothelial cells, saliva, nasal secretions, and respiratory fluid of patients with pulmonary KS. HHV-8 is most likely transmitted sexually. However, not all KS cases are cutaneous (skin). Interferon, liposome, and Taxol are some treatments. The retinoids apparently downregulate interleukin-6. So, how does the LGND gel work? And wouldn't it only be effective in localized cutaneous lesions? Certainly it could not be a treatment for all cases of KS, which can occur in HIV+ patients who do not have AIDS (similar to other HIV related malignancies, such as lymphomas). Please educate me. Thanks. |
