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Biotech / Medical : BTX BioTime
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From: seminole4/21/2015 4:49:59 PM
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BioTime and its OncoCyte subsidiary announce initial data from a large, prospective clinical study that showed the potential of PanC-Dx as a non-invasive, blood-based diagnostic test to screen for multiple types of human cancers, including breast cancer12:02 PM ET, 04/20/2015 - Briefing.com
Early data showed that PanC-Dx identified a mean concentration of COL10A1 protein in sera of breast cancer patients (n=33) that was 35% higher than the mean COL10A1 value in sera of normal individuals (n=32). No significant differences were noted when comparing breast cancer patients to patients with confirmed benign disease suggesting that additional biomarkers may be necessary to discriminate these two populations.
Based on this data, PanC-Dx offered improved performance as compared to the commercially available enzyme-linked immunosorbent assay (ELISA) manufactured with polyclonal antibodies that study investigators previously used in analyzing over 400 serum samples from healthy volunteers and cancer patients. Evaluation of the performance of PanC-Dx demonstrated 86% area-under-the-curve (AUC) of the Receiver Operating Characteristic (ROC) curve, which determines the level of specificity and sensitivity of the product. The polyclonal ELISA demonstrated 74% AUC of the ROC curve.
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