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Pastimes : vitamins herbs supplements longevity and aging
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To: Pogeu Mahone who wrote (12867)10/20/2015 12:58:48 AM
From: E. Charters  Read Replies (1) of 17056
 

It isn't that simple:

"Does N-acetyl cysteine play biased role in cancer ?

I desired to learn out from oncologist working particularly on NAC like antioxidant and cancer. My first query to know regards to the basal expression of NAC in human and does the expression of NAC altered by other nutrient supplements like Indole 3 Carbinol. Surprisingly I found the peaks on basis of NMR and GC study in sera. Now, coming to my query for NAC, since Jan 2014, Nuture news published article on entitle "Antioxidants speed cancer in mice" by Ledford which evidenced by many articals V.I. Sayin et al., “Antioxidants accelerate lung cancer progression in mice,” Science Translational Medicine, 6: 221ra15, 2014 and 2more articles however several of study of decades represents chemopreventive as well as anti cancerous effects of NAC, which it puts in clinical trials. Is it true conclude like antioxidant cause more harms in cancer than good raised by Andy Coghlan and other also. How do you look this?"

"

Shankar:

It is well known that antioxidants are associated with a checkered history in the broad context of their purported potentialities in the chemoprvention of cancer or treatment. Recently, it was reported that the dietary antioxidants, N-acetyl-L-cysteine (NAC) and vitamin E hastened the progression of lung tumorigenesis in mice. Antioxidant activity (AA) is a chemical or molecular property of a compound. Molecules with AA activity can impair the levels of reactive oxygen and nitrogen species (ROS and NOS) in cells. However they also can accentuate the proliferation rate of cancer cells. The consequences are increased tumor burdens and attenuated survival. Impaired expression of the tumor suppressor gene protein, p53, can evoke higher rates of cellular proliferation. Neither NAC and nor vitamin E influenced tumor growth in mice that did not possess p53.

A role for ROS in promoting cell motility during stress situations in leukocytes has been recently reported; treatment with NAC mitigated the increased enhanced, stress-induced migration potential of bone marrow leukocytes."



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