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Biotech / Medical : momo-T/FIF

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To: scaram(o)uche who wrote (10096)	12/1/2015 12:20:52 PM
From: scaram(o)uche	Read Replies (1) of 12215

I was originally set to do my first postdoctoral studies with this guy at Jackson Labs..... jordanfernald.com After instead choosing Max Planck, Tuebingen, I drove into iron curtain Czechoslovakia and Prague with smuggled scientific supplies that Don needed to get to collaborators. Anyway.... Dr. Bailey established strains of congenic mice that differed only by "minor histoincompatibility antigens". I've done tons of tail skin grafts using these (and other) mouse strains, and have respect for transplantation antigens that elicit weak immune responses (bringing story back to Adaptimmune, Nantkwest et al). I'd actually like to breed some of his strains, some of which are probably preserved via embryos in liquid nitrogen. There's no fundamental difference, from the view of a T cell, between a transplantation antigen and a tumor-ass'd antigen. These mice could be used to screen for immune enhancers that will allow deep digging beyond PDL1, CTLA-4 etc.

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