Wishing you all nice hollidays. IMO this isnt the 1st nor last time we will see the stock go down like this. You must ask yourself is it because a a fundamental change or not. Following is a article then a comment from myself.
Chest 1997 Dec;112(6):1699-1701
Vasculitis and bronchiectasis in a patient with antibodies to bactericidal/permeability-increasing protein and alpha1-antitrypsin deficiency.
Mahadeva R, Zhao MH, Stewart S, Cary N, Flower C, Lockwood M, Shneerson J
[Medline record in process]
A patient with alpha1-antitrypsin deficiency is reported herein; this subject developed aggressive bronchial disease and recurrent cutaneous vasculitis after pulmonary infection with Pseudomonas aeruginosa. Autoantibodies to neutrophil cytoplasmic antigens were detected, which produced granular cytoplasmic staining by indirect immunofluorescence with specificity for a newly characterized antigen: bactericidal/permeability-increasing protein (BPI). The bronchial disease and vasculitis improved, and the IgA anti-BPI titer fell after antipseudomonal treatment. This raises the possibility that anti-BPI antibodies contributed to both the bronchial disease and vasculitis.
My comment----------is conversely, if anti-bpi raises the possibility of lung problems etc, then it because of a lack of funtioning bpi, therefore bpi may solve this problem, especially nonreactive bpi21.
Of futher note, all indications seem to point to the lung as primary point with bpi.
Normal disclaimers, value all I say as worthless. bob |
