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Biotech / Medical : ARIAD Pharmaceuticals

ARIA 23.99

0.0%

Feb 17 4:00 PM EST

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From: jaybe	8/27/2016 5:34:14 PM
	of 4474

Pre-clinical evidence for pona in neuroblastoma... "In conclusion, ponatinib exhibits anti-tumor efficacy in NB by inhibiting FGFR1 signaling and blocking the activation of PI3K/AKT/mTOR and JAK/STAT3 signaling pathways, as evidenced by both in vitro and in vivo assays. Ponatinib also enhanced Dox-induced cytotoxicity in NB cells. Moreover, ponatinib showed anti-tumor efficacy in an orthotopic xenograft NB mouse model by blocking the activity of PI3K/AKT/mTOR and JAK/STAT3 signaling pathways. Collectively, our study provides compelling evidence that ponatinib is able to inhibit tumor growth as a single agent or combined with other therapeutic agents like Dox." impactjournals.com

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