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Biotech / Medical : Lidak Pharm. [LDAKA]
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To: telebob who wrote (786)1/4/1998 2:04:00 AM
From: luis a. garcia  Read Replies (2) of 1115
 
This is one of these knit picky gourmet things that really confuses me too.. telebob... The null hypothesis the Medicine in this case is better than the placebo. the P numbers come in inside the 95% confidence which is as required to prove the null hypothesis... then all this hype about the placebo numbers and lack of numbers... Now I am not saying it is not justified... I just simply don't quite understand the concern. Regardless of when the placebo outbreaks were concluded in time The statistics still showed significance.

Now look at it a different way in order to prove 95% confidence what is the minimum time between cures in each case??? This poses a rather interesting statistic problem... Best we can do is say if 8 days is baseline for no treatement i.e. placebo group then must be around 8 days and Lidakol treated group is less than that... but How much less?? is less?? I guess that is the rub.. However everyone gets better regardless...in time. Then the null hypothesis needs to be time
related in order to make any sense... and if it is then we know the P numbers show the difference IS STATISTICALLY SIGNIFICANT...so guys take two aspirin and call me in the morning....
Don't forget the BIG thing is the secondary end points which Jeff Weinress alluded to ...LIDAKOL if used when the first tingle is felt can SPARE some people the whole ORDEAL..... that is one to celebrate...FDA should fastrack this medicine....ASAP.
CHeezzzz
luis
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