Evan Dimmer,Re: JOUR OF UROLOGY,MUSE/PRAZOSIN ARTICLE:
"I am certainly no doctor, and definitely have no experience with MUSE,so could someone please translate the second half of this statement taken from the 10-Q, in terms a non-doctor would understand? What is the difference between MUSE and the "second product candidate"? What does the prazosin add?".
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Here is the original article ( it was an abstract ) as presented at the April '97 AUA New Orleans meeting. I could not scan the figures in. Anybody can get this article at your local hospital's library.
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The Journal of Urology
( Supplement )
Volume 157, April 1997, Number 4, Page 181
AUA Ninety-Second Annual Meeting
April 12-17,1997, New Orleans
ASTRACT No 703
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A COMPARISON OF TRANSURETHRAL ALPROSTADIL AND ALPROSTADIL/PRAZOSIN COMBINATIONS FOR THE TREATMENT OF ERECTILE DYSFUNCTION (ED)
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Ronald W. Lewis, Augusta, GA; Charles B. Brendier, Chicago, IL; Arthur
L.Burnett, Baltimore, MD, Robert G. Ferrigni, Scottsdale, AZ,. Wayne
J.G. Hellstrom, New Orleans, LA; Harin Padma-Nathan, Los Angeles, CA;
Nicholas A. Romas and Ridwan Shabsigh, New York, NY; Thomas A. StameY,
Stanford, CA; Paul R. Young, Jacksonville, FL; Darby Stephens, Craig A.Peterson,
and Neil Gesundheit, Menlo Park. CA, on behalf of the VIVUS-MUSE Study Group (Presented by Dr. Lewis)
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INTRODUCTION:We have evaluated the potential benefit of adding the alpha 1- blocker, prazosin HCI to alprostadil in a transurethral ED therapy program.
METHODS: 415 patients with organic ED were dosed (double-blind) with up to 4 alprostadil and 9 alprostadii/prazosin combinations on separate days to permit within-patient comparisons.
RESULTS- Overall . 69% of patients reported intercourse on at least one dose. Each of the 9 A/P combinations produced higher rates of intercourse than did the respective component alone.
The figure shows, ( figure could not be posted )for 3 representative combination doses, patients who reported intercourse
Penile pain occurred in 7.6 to 19.8% of administrations. Hypotension was observed in 1.5 to 9.2% of administrations, most commonly following high A/P ddses.
CONCLUSIONS: Transurethral alprostadil and prazosin combinations were more effective than alprostadil alone in permitting men with chronic ED to achieve sexual intercourse.
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Evan, please note the authorship od DrPad-my-pocket Nathan who has, for the 2nd time, put his good name to an article attesting that MUSE works in ovewr 50% of patients. Shortly thereafter he reneged, in Barons.( Disclaimer: unless of course Barrons is lying in which case my deep apologies to Padma, and shame on Barrons. Sorry guys, can't
have it both ways, gg.).
TA |
