SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Juno Therapeutics Inc. (JUNO)
JUNO 86.960.0%Mar 6 4:00 PM EST
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: Biotech Jim who wrote (64)6/13/2017 6:00:11 PM
From: tuck   of 84
 
how to deal with patient crises and deaths in these fragile patient populations
There's the on/off switch concept from Bellicum, Ziopharm/Intrexon, and Kite/Cell Design Labs. Not seeing Juno involved in this, or developing collaborations to address the above issue (though their publications index does point to a Bellicum approach, I don't get the impression Juno is actually interested in using it).

Why not avoid the "on target/off tumor" effect altogether? I gather this has been Juno's approach, via bispecific CARs, since targeting one antigen seems to be insufficient. Though you don't see this mentioned on their website, their publications index points to this approach, too, and they have apparently been working on it for a couple of years.

This article is a good review: Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection

I find this effort, from a UCSF lab particularly interesting (and presumably available for licensing; there is a patent and applications): Precision Tumor Recognition by T Cells With Combinatorial Antigen Sensing Circuits

Also this one: Versatile strategy for controlling the specificity and activity of engineered T cells

But it seems there's no getting around the need for preconditioning, and its associated problems, as doing without it impacts efficacy too much. Unclear if these newer approaches can address this conundrum, but I hope so.

Cheers, Tuck
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News