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Technology Stocks : Investing in Exponential Growth
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From: Paul H. Christiansen6/14/2017 9:07:27 AM
   of 1084
 
For experimental cancer therapy, a struggle to ensure supply keeps up with demand



A transformative cancer therapy based on modified immune cells has lured doctors, companies, and patients alike, but many are hitting a frustrating roadblock: generating enough of these chimeric antigen receptor (CAR)-T cells to meet surging demand. The situation is fluid, with shortages cropping up in some places and easing in others. Doctors, meanwhile, are grappling with how best to distribute the experimental therapy among very sick patients in clinical trials.

“How do I allocate the resource in a way that’s fairest to everybody and that treats the most patients and potentially saves the most lives?” asks Stephan Grupp, a pediatric oncologist at the Children’s Hospital of Philadelphia (CHOP) in Pennsylvania. Grupp has offered CAR-T therapy to more than 150 children with late-stage acute lymphoblastic leukemia (ALL)—and worries that because of supply limitations, he can’t help more.

CAR-T cell therapy took the cancer world by storm in the summer of 2010. It involves removing a patient’s immune cells, genetically modifying them to fight their particular cancer, then transfusing them back. The approach is risky— some have even died from it—but for blood cancers in particular, it’s been remarkable, saving patients at the 11th hour and keeping some in remission for years.

sciencemag.org

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