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Geneva, Switzerland, 3 January 2018 - Addex Therapeutics ( ADXN.SW) announced today the signing of a licensing and collaboration agreement with Indivior PLC ( INDV.L) for global development and commercialization of ADX71441 for the treatment of addiction. ADX71441 is a potent, selective positive allosteric modulator (PAM) that potentiates GABA responses at the GABAB receptor. In addition, Indivior will fund a research program at Addex to discover additional GABAB PAM compounds.
Under the terms of the agreement, Addex will receive $5 million upfront, $4 million of committed research funding over the next two years, $330 million of potential development, regulatory and commercialization milestones and tiered royalties up to double-digit. Addex retains the right to select compounds from the research collaboration for certain indications outside addiction, including Charcot-Marie-Tooth type 1a neuropathy (CMT1A).
"As a world leader in developing and commercializing treatments for addiction, Indivior is the perfect partner to continue development of ADX71441 which has shown potential in several preclinical models of addiction," commented Tim Dyer, CEO at Addex. "This agreement is part of our ongoing strategy to secure resources to advance certain assets of our broad allosteric modulator pipeline with leading players in key markets." |
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