Zylo and Novan both use nitric oxide but Zylo has a sustained release feature to provide a single application effective for 24 hours, Novan does not.
Ref:
Zylö Therapeutics has an innovative sustained-release drug-delivery system that was developed by Joel Friedman MD PhD and Adam Friedman MD FAAD. The delivery system uses patented hydrogel-derived nanoparticles, called Nanopods™, to deliver—in a sustained and controlled manner—notoriously hard-to-deliver therapeutic agents through topical administration.
Pancoast said the nanoparticle-based drug delivery system is the brainchild of Dr. Joel Friedman, a professor of physiology and biophysics at the Albert Einstein College of Medicine, and Dr. Adam Friedman, an associate professor of dermatology at George Washington University.
In 2006, the father-and-son duo set out to create a sustainable delivery method for nitric oxide. The colorless gas, which is naturally produced by the human body, has been found to increase blood flow and improve circulation, which means more oxygen and vital nutrients being distributed to muscles, organs, and tissues. But nitric oxide is only active for a few seconds due to its small size, extremely short half-life, and instability.
After years of research, the duo created a biodegradable hydrogel containing silane composite nanoparticles that release nitric oxide over time. A reaction between sodium nitrite and a sugar generates nitric oxide during the manufacturing process. The concentration of nitric oxide released and the time required are controlled by altering the amount and molecular weight of other ingredients.
Nitric Oxide. 2008 Aug;19(1):12-20. doi: 10.1016/j.niox.2008.04.003. Epub 2008 Apr 14
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Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites.
Friedman AJ1, Han G, Navati MS, Chacko M, Gunther L, Alfieri A, Friedman JM.
Author information
Abstract
A new platform using biocompatible materials is presented for generating powders comprised of nanoparticles that release therapeutic levels of nitric oxide (NO) in a controlled and sustained manner. The capacity of these particles to retain and gradually release NO arises from their having combined features of both glassy matrices and hydrogels. This feature allows both for the generation of NO through the thermal reduction of added nitrite by glucose and for the retention of the generated NO within the dry particles. Exposure of these robust biocompatible nanoparticles to moisture initiates the sustained release of the trapped NO over extended time periods as determined both fluorimetrically and amperometrically. The slow sustained release is in contrast to the much faster release pattern associated with the hydration-initialed NO release in powders derived from glassy matrices. These glasses are prepared using trehalose and sucrose doped with either glucose or tagatose as the source of thermal electrons needed to convert nitrite to gNO. Significantly, the release profiles for the NO in the hydrogel/glass composite materials are found to be an easily tuned parameter that is modulated through the specific additives used in preparing the hydrogel/glass composites. The presented data raise the prospect that these new NO releasing nanoparticles can be easily formulated for use under a wide range of therapeutic circumstances.
PMID: 18457680 DOI: 10.1016/j.niox.2008.04.003
[Indexed for MEDLINE]
ncbi.nlm.nih.gov
Abstract of US2009297634 (A1)
The invention provides compositions for releasing nitric oxide (NO) comprising a matrix that encapsulates nitric oxide. Nitric oxide is released when the composition is exposed to an aqueous environment. The invention further provides methods of preparing the compositions and uses of the compositions for treating infections and disorders.
https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=9&ND=3&adjacent=true&locale=en_EP&FT=D&date=20091203&CC=US&NR=2009297634A1&KC=A1
| United States Patent | 8,333,997 | | Friedman , et al. | December 18, 2012 |
Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof
Abstract
The invention provides compositions for releasing nitric oxide (NO) comprising a matrix that encapsulates nitric oxide. Nitric oxide is released when the composition is exposed to an aqueous environment. The invention further provides methods of preparing the compositions and uses of the compositions for treating infections and disorders.
Inventors:Assignee:
| Friedman; Joel M. (South Orange, NJ), Friedman; Adam (New York, NY), Navati; Mahantesh S. (Bronx, NY) | Albert Einstein College of Medicine of Yeshiva University (Bronx, NY)
patft.uspto.gov |
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