RE: VKTX
Just finished CC (I like to sleep longer this days, :-))
While I am gratified that VK2809 did have positive primary and secondary, and most importantly NO safety (so far NO) issue at 10 mg/day dose (I care less for QOD regime, maybe they can introduce 5 mg/day dose???),....there is several points that make me MAD! IS THERE ANY BIO-COMPANY THAT CAN REPORT STRAIT FORWARD RESULTS???
First, when company switch the importance of the end-points (those are pHeHF subjects , not NASH) and exclude arm as trial progress without reporting,...I PISS ON THEM!
Second, when company report numbers for secondary and no numbers for primary (15-40%LDLc reduction relative to placebo is only range, and not mean/median),...I PISS ON THEM!
Third, when company is talking too-much about option to scale down dose,...THAN I ASK: "WHAT IS FUCKING WRONG WITH CURRENT DOSE/REGIMEN???"
Looking forward to full data presentation.
I was slow this morning, so full position on VKTX is still in place. |
