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Biotech / Medical : VD's Model Portfolio & Discussion Thread

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To: CYBERKEN who wrote (3948)	1/16/1998 2:29:00 PM
From: Vector1	Read Replies (2) of 9719

could you please expand on this?>> Sure. On Epilepsy there are other compounds available and they have put off further development because of scarce recources pending the migrane trials. On the Migrane trials their last trial failed to any difference from the placebo with a suspenion solution delivery of the drug. Now they are going to try a higher dose in a pill formation because relief is shown where they can get a high enough concentration in the plasma. They have no idea whether the higher dose in pill formulation will get a higher plasma concentration or whether different side effects will be caused. Clearly the body is metabilizing most of the compound before it gets to the bloodstream. Its a crapshoot and I wouln't invest anything until there are preliminary results from the dose escalation trials that will go forward on the tablet form. Further I was not impressed with management and the spinoff funded with VC money may never pay off. yes they kept 55% of the equity buy the VCs put their capital in on a senior (preffered stock basis). The amount of capital was $8m V1

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