The first two authors contributed equally to the work. Second author is from Irv's realm, and the conclusions/vision might be forced into a FTSV slant.........
"The current results suggest that, while activating macrophage antitumor phagocytosis, CD47 blockade might also inhibit CD8+ T cell antitumor activity. However, such inhibition might be overcome using PD-1 blockade, a cancer immunotherapy currently thought to function primarily via CD8+ T cell activation. Interestingly, it was recently shown that, similar to tumor-infiltrating T cells, tumor-associated macrophages also express PD-1 co-inhibitory receptors 73. Thus cancer therapies targeting PD-1 or its ligand could be activating macrophage functions as well as T cells. A combination of PD-1 and CD47 blockade could have synergistic effects by potentiating the antitumor activity by both macrophages and T cells."
Translation...... TRIL must be perfectly situated, abscopal immunity will pop up everywhere, and all cancers on Earth will be cured. Tomorrow!
Conclusion....... the share price would be $1,000/share, if not for the Nic/Parsons act. And I have some land in Florida that you must consider!
(Thanks for the pointer! Interesting work.) |
