|  | |  |  | Earnings out yesterday.  I think that DVAX has found its footing.  A few tidbits from last night's conference call.  A number of Kudo's from analysts, so expect some upgrades to be coming. 
 Let me highlight some recent wins as shown on Slide 5. Today, we reported HEPLISAV-B net sales of $3.9 million for the fourth quarter, a little more than the estimate we provided in January. This compares to $1.5 million for the third quarter. We reiterate our expectation that HEPLISAV operations will be profitable by the end of the year and we believe that over time, HEPLISAV can reach peach gross U.S. sales of around $500 million.
 
 
 While we are confident with our year-end goal, we know we should still expect monthly and quarterly fluctuations and that the rate of growth each quarter will also fluctuate. Each large institutional customer follows a unique position in purchase process and their associated time lines vary. In 2019, the timing of purchases by new customer entrants are very influential. Overtime though, they make repeat orders which settle into a more predictable pattern, thus becoming something like an annuity. Now whilst this trend is beginning in 2019, obviously, the genuine power of the annuity continues to grow overtime.
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