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Biotech / Medical : Madrigal Pharmaceuticals

MDGL 418.90

-2.0%

Oct 31 9:30 AM EST

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To: keokalani'nui who wrote (90)	4/5/2019 11:35:48 AM
From: Miljenko Zuanic	of 138

Thanks. It is not secret that wast majority of the NASH pts are obese/pre-diabetic/diabetic and they are already on medications (statins + TD2 drugs) that control lipids and glucose. Weight reduction is definitely PLUS. So, NASH candidates that will deal with NAFLD will/would be on top top the current treatment. In that light I was bit surprise on the restriction that they implemented for P3. It does not follow real world, IMO. Good things is that +450 subjects from first 900 will be F3, so it will be important to assess does controlling liver fat improve F in F-advance subjects, not only pre-fibrotic (F1). Still I am concern about length of the trial and placebo arm. Medical outcome is what count and contribute to economic value of the candidates.

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