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Biotech / Medical : Zonagen (zona) - good buy?
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To: Dr. Voodoo who wrote (1874)1/20/1998 11:24:00 PM
From: poodle  Read Replies (1) of 7041
 
1. First patent you mention is really interesting.
2. I am not sure why second is important. Isn't it about mixture, not phentolamine alone?

This is about paragraph I mentioned:

patent.womplex.ibm.com

Left, first paragraph:

"Phentolamine, which has been shown to have the potencial to induce erection when injected intracavernosally, has also been the subject of oral administration to test its effects in man having non-specific erectile insufficiency (Gwimp, Ann. Int. Md. 15 Jul. 1988, pp.162-163). In that study16 patients injested either a placebo or 50 mg orally administrated dose of phentolamine. "

This is a part of introduction. Introduction should provide relevant facts from history of the subject. For EACH fact you should provide REFERENCE, unless it is "common knowledge". Look at this text. It has two parts.

"Phentolamine, which has been shown to have the potencial to induce erection when injected intracavernosally," is about injection.

..." has also been the subject of oral administration to test its effects in man having non-specific erectile insufficiency". That's about oral phentolamine. For oral phentolamine there is reference: Gwimp. We will discuss it sometime later.

Where are the reference for the first part?
The question is: if there is no literature about phentolamine injection, how do you know it's working? If literature does exist, why not to put it into the text?
Contrargument could be: it is not important for this patent so we do not include it. Wrong. There is literature about papaverine injection and even textbooks.

You know the reason why paper cited by Asensio was not included. Still it was published 8 years before this patent filling and available in any med. database. Also, that's not the only paper.

Regards.
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