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Biotech / Medical : Zonagen (zona) - good buy?

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To: Tunica Albuginea who wrote (1900)	1/21/1998 9:57:00 PM
From: khrnyc	Read Replies (2) of 7041

Good evening TA The serum half life of intravenous phentolamine is 19 minutes. Approximately 13% of a single intravenous dose appears in the urine as unchanged drug. Specific data on Zona's Vasomax is not yet available. Despite your thoughtful speculations why it should not be so, mucosally absorbed phentolamine is actually quite safe. As was illustrated in presentations at the Second Annual Symposium on the Pharmacologic Management of Male Sexual Dysfunction in September, 1997, the two phase III Vasomax trials suggested that Vasomax was very safe, with the most common side effect being a stuffy nose. As for procardia, it was in fact never designed nor approved for sublingual use. The mechanisms of action of procardia and phentolamine are completely different. Procardia is a calcium channel blocker. Phentolamine is an alpha blocker. Rapidly dissolving and orally absorbed phentolamine (Vasomax) has been well studied and is safe when used in this way. Procardia never was.

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