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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ)

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To: Tunica Albuginea who wrote (4857)	1/21/1998 11:44:00 PM
From: Bradpalm1	Read Replies (1) of 23519

<<On to parag #14: " Persantine (dipridamole) is an example of a PDE inhibitor that has been used extensively as a vasodilator without major adverse effects ". The following corrections are in order: -Persantine has NEVER been used EXTENSIVELY as a vasodilator. -Persantine induced vasodilatation is regarded as an unwanted side effect. -Persantine's ONLY indication is to reduce platelet adhesiveness and thus prevent further blood clot formation in stokes, after by-pass etc.Most MDs feel that htis drug is essentially worhtless. it was used "extensively" 20 years ago when we didn't know better.>> Perhaps you should do some homework, Tunica. As BigKNY3 said, dipyridamole is a PDE inhibitor and IS used extensively as a vasodilator in clinical medicine. Have you ever heard of the dipyridamole-thallium cardiac stress test? This extremely common diagnostic study utilizes intravenous dipyridamole to act as a vasodilator of coronary arteries. BTW, dipyridamole is a Type V PDE inhibitor like sildenafil (Viagra). Just a friendly clarification. Bradpalm1

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