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Biotech / Medical : Zonagen (zona) - good buy?
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To: khrnyc who wrote (1952)1/22/1998 6:40:00 PM
From: Dr. Voodoo  Read Replies (1) of 7041
 
Dr. Rubin or Tokyo,

After having read Poodle's literature references could you please illustrate for the Medically Challenged(myself) exactly how:

1) The drug may be affected by gastrointestinal (GI) transit time
(how fast substances move through the GI tract).

2) Stomach ph can inactivate the drug.

3) The drug first goes to the liver and is metabolized and much is
inactivated (the so-called "first pass" effect)

Below are the references so you don't have do go back and look.

In a prospective study of 15 consecutive impotent patients we evaluated the erectile responses to intracavernous injections of standardized doses of papaverine and phentolamine alone and incombination. Of the 15 patients 13 achieved a full erection with the drug combination, whereas only 6 achieved a full erection with papaverine and 1 with phentolamine. Our results suggest an effective alternative to the use of papaverine alone, whose long-term sequelae have been shown to be deleterious.

REFERENCE 2
Br J Urol 1989 Jan;63(1):95-97

Effect of phentolamine on venous return in human
erection.

Wespes E, Rondeux C, Schulman CC

A group of 25 patients underwent Doppler penile blood examination and cavernometry before and after 5 mg of phentolamine injected intracavernously. The organic or psychogenic nature of impotence was determined by psychological testing, the intracavernous injection of papaverine, hormonal evaluation, neurological examination, Doppler penile blood flow measurement and cavernometry for vascular investigations. The intracavernous injection of phentolamine had no effect on the venous return and it provoked penile arterial dilatation. The erectile angle, which was also measured, was less evident than after the injection of papaverine. The results confirmed the fact that an increase in arterial inflow alone is not sufficient to induce a rigid erection in man.

Thanks in advance
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