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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ)

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To: Tunica Albuginea who wrote (4900)	1/23/1998 11:56:00 PM
From: Bradpalm1	Read Replies (2) of 23519

<<Braddy,Persantine is used for testing in the Thallium stress test, ie it does stress the heart under closely monitored conditions of a stress test; obviously stressing the heart as therapy is not advised. I left the stress issue out of my post because testing is not considered therapy. Intravenous iodine is also used extensively for catheterization purposes but nobody takes it for therapy . As far as therapy is concerned, the ONLY approved indication as per PDR is as an antiplatelet factor, anti-clotting. Rest assured that bringing up the stress cardiac factor is not going to ingratiate you to any prospective ED patients. As mentioned, most enlightened MDs don't use Persantine therapeutically; perhaps it is still used in marginal medical practice settings. Again, you are confusing the issues.The issue here is THERAPY. That is what we are talkng about, not diagnostics.>> Tunica, Don't trip over your semantics as you back-peddle away from your post. The ORIGINAL question posed by Gene to BigKNY3 was: what are "the effects of systemically inhibiting them (PDEs)". He didn't ask about the therapeutic or diagnostic roles of PDE inhibitors. He rhetorically questioned whether BigKNY3 was aware of the systemic physiological and pharmacological effects of these agents. The issue here is NOT therapy or diagnostics. It's whether any PDE inhibitors are currently being safely used in clinical medicine. The correct answer is that dipyridamole (Persantine) is indeed being currently utilized in populations of patients with known or probable atherosclerotic heart disease (secondary to the SAME risk factors which lead to ED) with negligible side-effects. Until we understand more about the pharmacokinetics and actions of sildenafil (Viagra), a similar PDE inhibitor, it's disingenuous to simply dismiss it due to its pharmacological classification. Bradpalm1

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