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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ)

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To: Bradpalm1 who wrote (4991)	1/26/1998 8:45:00 AM
From: Gene Voss	Read Replies (1) of 23519

Brad:<re persantines apparent safety and lack of side affects even though its a PDE 5 inhibitor> All enzyme inhibition is site specific and dose related.Persantine doesn't cause erections because of low doses probably or due to any number of other possibilities.I believe the PDE5 inhibitory pathway will require such high doses of sildenafil other PDE enzymes will also be inhibited to some degree thus increasing the side effects. I know the party line on specificity of sildenafil for PDE5 sites but I can't imagine it not causing systemic side effects if given in doses large enough to assist penile erection.Some additional PDE inhibition would have to occure. GV

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