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Biotech / Medical : Regeneron Pharmaceuticals

REGN 674.95

+3.1%

Nov 11 3:59 PM EST

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To: CuttingEdge Bio who wrote (2857)	3/22/2020 1:21:17 PM
From: Miljenko Zuanic	Read Replies (2) of 3557

<I'm not sure what point you're trying to make from the Cell paper.> My point is my concern that just binding to pipe/envelope-proteins on unactivated virus my not be sufficient to halt incubation on progress into full blown infections? Interesting, virus avoid immune system for prolonged time,...so how to break this tolerance and activate adaptive response? len is talking about passive immunization? Really? So, maybe more effective Abs approach is to block viral-RBD activation as well neutralization at activated stage. And that is what CELL paper talk about! Once virus enter cells and multiple to critical level, any Abs approach is less effective. However, in Ebola case (as described in NEJM), "The greatest reduction in mortality (minus 22.5 percent) across all study groups occurred with REGN-EB3 treatment in patients who were treated later in the course of their disease, when risk of dying from Ebola is greatest." REGN-EB3 demonstrate to be effective as TREATMENT, not only prophylactic agent. Was this due to TRUE knowledge of the Ebola biology and INTERVENTION POINTS Abs design, or just due to SUPERIOR mouse model and LUCK! I think former one. Unfortunately. So, should I (or any REGN SH) expect the same for nCoV? How much superior mouse model can help to develop effective drug for this different virus? That it is point where Street hype can influence distraction! And I am fighting DISTRACTION from 1996! So far, successfully. ;-)

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