Dauntless, I read the full article "Gas chromatographic determination of phentolamine (Regitine)in human in human plasma an urine" I read it back by the time I posted the Gwinup and Zorgniotti articles. I did not copy it, I did not post it because it did not answer my question.
It is not about phentolamine pharmacokinetics, but about the validity of the measurement technique itself. There is not a description of the levels achieved after administration of 20 mg of phentolamine, neither in urine, neither in plasma.
They did provided the sampling time, not the levels at each time, neither in blood, neither in urine.
You are inferring that the levels were low (wrong)they are saying that they were able to measure down to 5 ng/ml in plasma, and down to 25 ng/ml in urine (they measure higher levels, not provided). They wanted to prove that the technique was correct up to those very low levels. They did not provided the actual levels at each time of sampling, probably they do have the data somewhere else. I guess nobody was interested in that data at the time and was not published (Ciba-G did not put more money on it).
The numbers that Keith presented are reference nowhere.
The "fast disolving pill" does not altered the bioavailability of phentolamine from the GI track (less than 20% of the active compound is absorbed from gatrointestinal track).
Zorgniotti used a faster method, oral mucosa absorption and his subjects were advised to attempt coitus at 30 minutes (faster than 1.5 hours) and only 31.8% achieved a full erection vs placebo 13%. Not very good numbers. Remembers all patients with cardiovascular problems were excluded.
I do not discard that there are chances (very low) of the drug to work. But, with the information available I will not be a long.
I am not a short either.
Phentolamine alone directly in the penis does not work (as per Joe Podolski CC ). |
