Why is Coronavirus Research Bogging Down ?
First, the initial response, focused on decoding the genetics of the virus, has not been followed up with a specific identification (and publication) of particular protein sequences transcribed from the RNA... which proteins, in any effort other than prevention efforts focused on the inhibition of transcription itself, are the targets, as operational elements whose functions must be explained, and countered, or exploited, for any anti-viral "disruption of function" strategy to work.
Required is a clear definition of the atypical or "novel" proteins. You have to know the target, in this case targets, to have a chance of success.
Second, critical elements in understanding include... "no silver bullet"... because multiple targets require a range of specifically tasked and precision guided silver bullets. So the requirement is for a definition of an overall integrated approach, with a layering of responses functional at different levels, responses addressing different targets, each with that layered approach.
Third, the variables in viral expression have not been explained... and probably cannot be without first completing a proper description of the proteins (first, above):
The differences between symptomatic and asymptomatic expressions, the variables in incubation period, the reported failure in development of resistance in recovered patients, and otherwise, the recurrence of active infection in patients who have tested as virus free... all need to be explained, both as a function of the virus proteins, and as a function of the genetic, dietary, medical treatment, environmental factors, or other variables in patient populations. |
