Dauntless,
Went and read J chromatography articles did not copy, no quarters, very grumpy thing :(
What my interpretation of what I read is:
The phentolamine levels they measured in blood were low. I forgot the time points. They did not mention numbers. Go forth and check the patent application. In this chrom. paper they administered a 20 mg dose. Look at Zonagen's own numbers. They indicate that the mean was right around 5 ngs. Also look at the standard deviation. What this says to me irrespective of time points is that you cannot make a reliable determination of phentolamine levels in blood by looking at that paper based on a 20 mg dose. As a result, Zonagen went to higher doses.
Among interesting points I got out of the paper were half life of 19 minutes. Also a bunch of cool words like rapidly metabolized, and conjugated and unconjugated. I am not an analytical chemist, but I have a pretty good understanding what they did to develop their assay. Among the things I still can't quite glean is whether or not they actually measured the metabolite in urine or just said it was difficult. I would be careful in interpreting the urine data, that one is a little tricky.
There was one other reference to an HPLC determination of phentolamine levels down to like 15ng/ml. More on this later, if it pans out.
Regarding Asensio, and lawsuits and other stuff. I do not want to be involved. I don't care about any of this vindictive schmeg. I would advise you to talk to someone who can get a real expert determination of what is going on and don't rely on my chemical or scientific judgement and opinions. (I am not and do not want to be an expert, I just pretend to be one on the internet!) My interpretations of the data are just that, my interpretations, which I have shared with you and others.
Still fetching papers, they're getting popular around here!
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