I'm not sure if this info below has been previously posted. It also makes me question what is so special about Zonagen's drug.
There are two other ways you may be able to help your patients: URETHRAL GEL and ORAL PHENTOLAMINE. Many patients have successfully tried these alternatives to injectables. The urethral gel is inserted into the urethra via a special syringe or applied topically. Oral phentolamine can be taken in an oral dosage which can be swallowed or placed under the tongue. This oral phentolamine may be an alternative to the injection for many impotent men. "Satisfactory erection with penetration can be obtained in impotent men by the oral or buccal administration of the alpha-adrenergic antagonist, phentolamine. This agent is also used in conjunction with papavarine HCl for intracavernous injection." 1
1. "Experience with buccal phentolamine mesylate for impotence," Zorgniotti, A.W., Dept. Of Urology, New York University School of Medicine, NY 10016, Int J Impotence Res., 1994 Mar, 6:1, 37-41.Order this document
Int J Impot Res 1994 Mar;6(1):37-41
Experience with buccal phentolamine mesylate for impotence.
Zorgniotti AW
Department of Urology, New York University School of Medicine, NY 10016.
Satisfactory erection with penetration can be obtained in impotent men by the oral or buccal administration of the alpha-adrenergic antagonist, phentolamine. This agent is also used in conjunction with papaverine HCl for intracavernous injection. The previous observation by Gwinup, that 50 mg of phentolamine HCl po, 1.5 hours before coitus resulted in erection in 11/16 patients, is confirmed. This study, using phenoxybenzamine as the placebo, was repeated with success in 36/85 (42.3%) patients. Because of cost and to decrease the waiting time, a buccal form of phentolamine mesylate was administered (20 mg) with erection and penetration in 21/69 (31.8%). There was no correlation between the degree of penile vascular insufficiency or age and the effectiveness of phentolamine. Buccal phentolamine is shown to increase flow velocity in the dorsal penile artery. Phentolamine produces minimal side effects, including hypertension in the subjects.
Publication Types:
Clinical trial
PMID: 7517275, UI: 94290566 |
