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Biotech / Medical : Neurobiological Tech (NTII)
NTII 0.00010000.0%Mar 7 3:00 PM EST
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To: Cacaito who wrote (237)1/28/1998 11:27:00 PM
From: Dr. John M. de Castro  Read Replies (2) of 1494
 
The p value is probably correct. They are being real liberal with what they are calling significant. But, keep in mind that this is a Phase II that is not powered to show significance.

I strongly doubt that memantine is acting as a neuroprotectant in this case. NMDA blockers appear to act directly on pain input into the spinal cord and that is the suspected mode of action for memantine. The neuroprotection occurs when there is overstimulation of glutamate receptors in the nervous system that can produce neural apoptosis. This occurs as a result of head trauma, stroke, AIDS etc. To my knowledge this process is not involved in diabetic neuropathy.

My guess is that the market reaction will be mildly positive. However, if I were that great at predicting the market, I wouldn't need to be analyzing research results :-)

My second guess is that the real action will take place when money and partners appear. The market is real worried about the viability of NTII as a going concern. So I suspect that there won't be a big run up in the stock value until the capital needed to continue the clinical development is obtained. I'm looking forward to an interesting month or two of developments.

John de C
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