In 2018, Barrett was among the 7th Circuit judges who sought reconsideration of a decision that invalidated a Republican-backed Indiana law requiring that fetal remains be buried or cremated after an abortion. The Supreme Court in 2019 reinstated the law.

In 2019, Barrett also voted for rehearing of a three-judge panel’s ruling that upheld a challenge to another Republican-backed Indiana abortion law before it went into effect. The measure would require that parents be notified when a girl under 18 is seeking an abortion even in situations in which she has asked a court to provide consent instead of her parents, as was allowed under existing law. The Supreme Court in July tossed out the ruling and ordered the matter to be reconsidered.

In June, Barrett dissented when a three-judge panel ruled in favor of a challenge to Trump’s policy to deny legal permanent residency to certain immigrants deemed likely to require government assistance in the future. In January, the Supreme Court, powered by its conservative majority, allowed the policy to take effect.

And she is a member of "People of Praise", which is a semi-secret Catholic Society and has an authoritarian structure.