| | | For any of you who are not going to get the vaccine but are concerned about covid, I've been taking most (in bold) of this prophylactic protocol (pages 6-7 in link below) since March since I am high risk (age 76). IMHO the most important are D3, Quercetin and zinc. Quercetin is a zinc ionophore (as is HCQ but OTC and without side effects) which facilitates absorption of the zinc. I am strongly considering adding Ivermectin (see page 3 in link below) which has recently been added based on good results in many clinical studies. This cocktail is inexpensive, widely available and without the need for prescriptions. I wonder how many lives might have been saved if more people had been aware of this since March? I am not a doctor but this protocol has been developed independently by multiple doctors.
• Vitamin D3 1000–3000 IU/day. I take much more resulting in a 80 ng/mL blood test result, which is still below the upper limit of 100 ng/mL). Note RDA (Recommended Daily Allowance) is 800–1000 IU/day. The safe upper-dose daily limit is likely < 4000 IU/day. [1–22] Vitamin D insufficiency has been associated with an increased risk of acquiring COVID-19 and from dying from the disease. Vitamin D supplementation may therefore prove to be an effective and cheap intervention to lessen the impact of this disease, particularly in vulnerable populations, i.e. the elderly, those of color, obese and those living > 45o latitude. [7–22]
• Vitamin C 500 mg BID (twice daily) and Quercetin 250 mg daily. [23–34] It is likely that vitamin C and quercetin have synergistic prophylactic benefit. [35] It should be noted that in vitro studies have demonstrated that quercetin and other flavonoids interfere with thyroid hormone synthesis at multiple steps in the synthetic pathway. [36–39] The use of quercetin has rarely been associated with hypothyroidism. The clinical impact of this association may be limited to those individuals with pre-existent thyroid disease or those with sub-clinical thyroidism.[40] In women high consumption of soya was associated with elevated TSH concentrations.[41] The effect on thyroid function may be dose dependent, hence for chronic prophylactic use we suggest that the lowest dose be taken. Quercetin should be used with caution in patients with hypothyroidism and TSH levels should be monitored. It should also be noted quercetin may have important drug-drug interactions; the most important drug-drug interaction is with cyclosporin and tacrolimus. [42] In patients taking these drugs it is best to avoid quercetin; if quercetin is taken cyclosporin and tacrolimus levels must be closely monitored.
• Melatonin (slow release): Begin with 0.3 mg and increase as tolerated to 2 mg at night. [43–50]
• Zinc 30–50 mg/day (elemental zinc). [23,30,32,33,51–55] • B complex vitamins [56–60]
• Ivermectin for postexposure prophylaxis (see ClinTrials.gov NCT04422561). 0.2 mg/kg (12 mg) immediately then repeat day 3.
• Ivermectin for pre-exposure prophylaxis (in HCW) and for prophylaxis in high risk individuals (> 60 years with co-morbidities, morbid obesity, long term care facilities, etc). 0.15–0.2 mg/kg (or 12 mg) Day 1, Day 3 and then every 4 weeks. [5,61,62] (also see ClinTrials.gov NCT04425850). NB. Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs and certain anti-fungal drugs.
• Optional: Famotidine 20–40 mg/day [55–61]. Low level evidence suggests that famotidine may reduce disease severity and mortality. However, the findings of some studies are contradictory. While it was postulated that famotidine inhibits the SARSCoV-2 papain-like protease (PLpro) as well as the main protease (3CLpro) this mechanism has been disputed.[58] Furthermore, a single study suggested that users of PPI’s had a significantly increased odds for reporting a positive COVID-19 test when compared with those not taking PPIs, while individuals taking histamine-2 receptor antagonists were not at elevated risk.[62] This data suggest that famotidine may be the drug of choice when acid suppressive therapy is required.
• Optional/Experimental: Interferon-a nasal spray for health care workers [54]
https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-–-A-Guide-to-the-Management-of-COVID-19.pdf |
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