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Biotech / Medical : Harvard Scientific (HVSF)Hot$$- male impotency medicine

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To: John A. Paul who wrote (2890)	2/1/1998 4:10:00 PM
From: Tunica Albuginea	Read Replies (1) of 3906

John Paul,THE WEAKNESS OF HVSF IS: THEY DON'T HAVE A PATENT ON THE DELIVERY;VIVUS HAS THAT, ( patent # 587 , siliconinvestor.com Let me explain and ask: This is the HVSF Patent claim announcement: biz.yahoo.com It states: -" the U.S. Patent and Trademark Office that it will issue patent no. 5,718,917 entitled ''PGE-1 CONTAINING LYOPHILIZED LIPOSOMES FOR USE IN THE TREATMENT OF ERECTILE DYSFUNCTION'' to the company." As I read that, THIS IS A PATENT to THE L I Q U I D Liposomal &Alprostadil/PGE Further down the news release states: -"The company's patented process allows the Prostaglandin E-1 to be administered as a liquid via a painless delivery system". My QUESTION is : W H E R E IS THE PATENT to the D E L I V R Y S Y S T E M ??????? The answer is : HVSF does NOT have a patent ; VIVUS has the patent. Here it is: ( This is ONLY PART of the VIVUS PATENT ): Message 3310565 I have othe concerns about liquid Alprostadil: Message 3314238 Re: in regards to HVSF patent.Several points why I fell comfortable: -I asked Dave Yntema ,( Chief Financial Officer at Vivus ) 7 months Ago about " whether Vivus can defend their patent if somebody found a way to insert a liquid through a catheter into the urethra " . ( interestingly enough, at that time I had no idea who HVSF was or that they were working on such a system !!!)His answer was yes.They had just come through defending a patent infringement in the UK. -A gel is going to present several tecnnical problems: =More volume will be needed to allow for residual adhering to plastic. =More vol will mean: more expense; it will be difficult to dose, if patient does not express out all of it. =the gel will be distributed more widely along the length of the urethra.That means that some of it may go all the way back at the base where it could theoretically go all the way back into the bladder. =in fact if the massage is done inappropriately, the gel could be massaged right out of the urethra into the bladder or come out the front.That means that the patient would have to squeeze tight his urethral meatus(the opening of the urethra in the penis) to prevent the gel from coming out during the massage;sort of awkward to squeeze with one hand and massage with the other. -Most importantly, the greater distribution will cause a greater degree of absorption of the material thus greatly enhancing the potential for systemic absorption and thus hypotension and systemic side effects. -preservtion of a liquid in plastic creates problems of absorption & degradation of the material by the plastic. A very significant aspect that people have significantly missed here however is the Irwin-Urology-torch-bearer-Goldstein: he is the one that said MUSE /Alprostadil doesn't work very well in the urethra and here he is advising HVSF about how to administer Alprostadil though the urethra!!!!! Alprostadil in the urethra does the same thing whether ina pellet or a liquid! One final point:other patent attorneys or interested parties/potential HVSF investors must have looked at this: why is HVSF languishing at 96 cents a share? Maybe somebody DID take Gene's advice and forked over $100 to an attorney for a Vivus/HVSF patent search and thus subsequently decided to dump HVSF shares at 96 cents!! Again, IMHO, HVSF WITHOUT A PATENTED DELIVERY SYSTEM (now owned by Vivus is totally worhtless; $1/share!! THE MARKET HATH SPOKEN!!! TA PS For those of you who would like to have a RETURN on your money consider Buying Vivus! Here is the latest, al in the SI thread!!: Message 3309509 Go Vivus!!

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