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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: Oliver & Co who wrote (3739)	2/6/1998 1:21:00 AM
From: billkirn	Read Replies (2) of 6136

Oliver&Co, John, Margie: An article in the SF Chronicle pageA7 2/5/98 indicated that the rumors of "Buffalo Hump" and "Protease Paunch" symptoms are beginning to be documented..... Chemicals essential to metabolism that resembled the portion of HIV protease targeted by the drugs, including an LDL-Cholesterol receptor on liver cells. If the HIV drugs were to damage the receptor, he suggested, the results would be lipid absorption problems in the liver. Has any DR. on this thread noticed this symptom emerging with their patients? Is this something to be concerned about as protease inhibitor usage continues? Could this be a limitation on usage of protease inhibitors? Could this mean that these drugs should not be used until absolutely needed, rather than immediately after detection of HIV. Apparently only 21 cases have been sent to the FDA for review so far. I think we need to keep track of this issue, as it might seriously impact the use of Protease Inhibitors in the future. I would appreciate any comments and observations on this subject. Thanks Bill

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